Uterine Fibroids and PHRT: Are Leiomyomas a Contraindication to Hormone Restoration?

 One of the more challenging questions in perimenopausal hormone management is what to do when a woman needs hormonal support but already has hormone-responsive uterine pathology. Consider this clinical scenario: A…

Stop Treating the Lab. Start Treating the Physiology.

Stop Treating the Lab. Start Treating the Physiology. Why hormone receptor biology and not just hormone levels may be the missing link in hormone therapy "My patients are still symptomatic." It's a phrase we hear often from…

Perimenopause Is Not a Deficiency State. It Is a Transition.

Perimenopause Is Not a Deficiency State. It Is a Transition. Salome Masghati, MD OBGYN Perimenopause is often framed as a simple hormone deficiency problem. Estrogen declines. Progesterone falls. Replace what is missing. After…

Stem Cell Regeneration Cycle

PHRTTM: Restoring the Body’s Native Stem Cell Regeneration Cycle By James Nagel, MD In recent years, regenerative medicine has shifted the focus of healthcare from simply managing disease to actively restoring health. At the center…

Anxiety

Hormones, Mood, and Midlife: Reframing Anxiety in Perimenopause and Menopause By James Nagel, MD Anxiety is common, disabling, and often under-contextualized in midlife women. In the United States, an estimated 19.1% of adults experience…
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Hormones & Cancer

Rethinking Breast Cancer Risk: The Truth About Hormones and Prevention By Julie Taguchi, MD, Hematologist-Oncologist For years, women have been told that hormone therapy increases the risk of breast cancer—a long held belief since…

Bone Density

The Bone Truth: Why Physiologic Hormone Restoration Works By James Nagel, MD As a physician who has been practicing Physiologic Hormone Restoration Therapy (PHRT®) for many years, I’ve seen firsthand how this approach doesn’t…

Endometriosis

  Rethinking Endometriosis: What If We’ve Been Treating It All Wrong? By James Nagel, MD If you had asked me early in my career what to do for a patient with endometriosis, I probably would’ve given you the standard response:…

Secondary Premature Ovarian Failure

Restoring Life and Hope: A Case Study in Secondary Premature Ovarian Failure By Rebecca Provorse, ND As a physician, I encounter patients facing unique and challenging health journeys, and each one reminds me of the transformative…

Hormones & Cardiovascular Health

A Transformational Case in Cardiovascular Health and Hormone Therapy By Greg Wolf, MD As a physician deeply involved in hormone restoration therapy, I’ve encountered many compelling cases over the years. However, some cases stand…